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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MEX3D All Species: 7.58
Human Site: S591 Identified Species: 18.52
UniProt: Q86XN8 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86XN8 NP_976049.3 651 64883 S591 S R K P P S A S S A P A L A R
Chimpanzee Pan troglodytes XP_524036 740 76557 S665 S R K P P S A S S A P A L A R
Rhesus Macaque Macaca mulatta XP_001096989 464 49865 H430 A A L V P C G H N L F C M E C
Dog Lupus familis XP_855104 551 56066 A504 A R E C V V C A E G E A M A A
Cat Felis silvestris
Mouse Mus musculus Q3UE17 643 65311 T569 E G N H K P S T T A A N S S A
Rat Rattus norvegicus XP_234921 697 70530 S622 S E G N H K P S T T A A N S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515618 613 64857 E569 C M V C Y E S E V I A A L V P
Chicken Gallus gallus XP_418202 443 47323 H409 A A L V P C G H N L F C M E C
Frog Xenopus laevis A1L3F4 507 54145 G472 I A A L V P C G H N L F C M E
Zebra Danio Brachydanio rerio NP_001074462 537 57239 P500 E V I A A L V P C G H N L F C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.6 42.4 63.9 N.A. 77.5 68 N.A. 52.3 49.7 43.6 43.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 78.5 50 67.9 N.A. 81.8 73.1 N.A. 61.7 56.3 53 52.3 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 20 N.A. 6.6 20 N.A. 13.3 6.6 0 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 26.6 46.6 N.A. 33.3 33.3 N.A. 20 26.6 0 6.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 30 30 10 10 10 0 20 10 0 30 30 50 0 30 20 % A
% Cys: 10 0 0 20 0 20 20 0 10 0 0 20 10 0 30 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 20 10 10 0 0 10 0 10 10 0 10 0 0 20 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 20 10 0 10 0 % F
% Gly: 0 10 10 0 0 0 20 10 0 20 0 0 0 0 0 % G
% His: 0 0 0 10 10 0 0 20 10 0 10 0 0 0 0 % H
% Ile: 10 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 20 0 10 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 20 10 0 10 0 0 0 20 10 0 40 0 0 % L
% Met: 0 10 0 0 0 0 0 0 0 0 0 0 30 10 0 % M
% Asn: 0 0 10 10 0 0 0 0 20 10 0 20 10 0 0 % N
% Pro: 0 0 0 20 40 20 10 10 0 0 20 0 0 0 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 30 0 0 0 0 0 0 0 0 0 0 0 0 20 % R
% Ser: 30 0 0 0 0 20 20 30 20 0 0 0 10 20 10 % S
% Thr: 0 0 0 0 0 0 0 10 20 10 0 0 0 0 0 % T
% Val: 0 10 10 20 20 10 10 0 10 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _